Pathophysiologically Informed Biomarkers for Treatment Response

The main goal of the study is to examine the ability of three non-mutually exclusive pathophysiologically based biomarkers (task fMRI, diffusion measures of free water, and neuromelanin-sensitive MRI) to predict treatment response in individuals with recent-onset psychosis. We plan to measure each of these biomarkers over the period of 1 year, followed by a multi-tiered set of analyses to test the predictive power of each biomarker. We will use advanced machine and deep learning tools to assess how these measures together predict a positive response to treatment.